Diabetes mellitus and survival in cystic fibrosis patients after lung transplantation

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• 作者：Markus Hofer^a ; Christoph Schmid^b ; Christian Benden^a ; Rudolf Speich^c ; Ilhan Inci^d ; Walter Weder^d ; Annette Boehler^a ; ^{capybara@compuserve.com}
• 关键词：Cystic fibrosis ; Lung transplantation ; Diabetes mellitus ; Bronchiolitis obliterans syndrome
• 刊名：Journal of Cystic Fibrosis
• 出版年：2012
• 期刊代码：298_15691993
• 类别：med
• 出版时间：March, 2012
• 卷：11
• 期：2
• 页码：131-136
• 文件大小：179 K

摘要

Background

Diabetes mellitus (DM) is common in CF and associated with more severe disease. It is unclear whether DM influences outcome of lung transplantation (LTx).

Methods

One hundred twenty-three CF patients evaluated for LTx at our centre were included. Survival was calculated.

Results

Patients with and without DM did not differ with regard to gender, age, FEV₁ and BMI prior to LTx. Eighty patients (65%) had a diagnosis of DM before and 13 (11%) only after LTx. Recipients with DM had a significantly higher 1- and 5-year survival (89%and 71%) than those without (71%and 51%). In the multivariate Cox-regression analysis, DM had no impact on LTx-survival.

Conclusions

One- and five-year survival rates after LTx tend to be better in CF recipients with DM compared to those without DM. No impact of DM on the development of BOS was found.