Relationship of delay aversion and response inhibition to extinction learning, aggression, and sexual behaviour
- 作者：Filip Van den Bergh ; Marjolein Spronk ; Leila Ferreira ; Emilie Bloemarts ; Lucianne Groenink ; Berend Olivier and Ronald Oosting
- 关键词：Stop-signal task ; Delayed reward task ; Extinction test ; Impulsivity
- 刊名：Behavioural Brain Research
- 出版年：2006
- 期刊代码：3_01664328
- 类别：neu
- 出版时间：25 November 2006
- 卷：175
- 期：1
- 页码：75-81
- 文件大小：195 K
摘要
Impulsivity is an important symptom of many psychiatric disorders, and can be divided into two subtypes: response inhibition deficits and delay aversion. In the present study, we investigated the relationship between delay aversion and response inhibition, both to each other and to locomotion, extinction of conditioned responses, sexual behaviour, and aggressive behaviour. To that end, we quantified the behaviour of 24 rats in several tests. To measure response inhibition, rats were trained in a stop-signal task. In this operant task, rats were rewarded food if they inhibited execution of a response after presentation of an audible stop-signal. Delay aversion was measured in an operant task in which rats made a choice between a small, immediately available reward and a large reward available after a delay. The results showed that delay aversion and response inhibition were independent. Responses during extinction and various measures of aggressive behaviour were positively correlated to delay aversion. The speed of go-trials in the stop-task was correlated to non-aggressive behaviour. We conclude that the role of response inhibition in various behaviours is small, but delay aversion in particular contributes to several other behaviours, such as aggressive behaviour and extinction.