Cross-protection by MF59™-adjuvanted influenza vaccine: Neutralizing and haemagglutination-inhibiting antibody activity against A(H3N2) drifted influenza viruses
- 作者：Filippo Ansaldi ; Sabrina Bacilieri ; Paolo Dur ; o ; Laura Sticchi ; Laura Valle ; Emanuele Montomoli ; Giancarlo Icardi ; Roberto Gasparini ; Pietro Crovari
- 关键词：Influenza ; MF59™ ; Antigenic drift ; Cross-protection
- 刊名：Vaccine
- 出版年：2008
- 期刊代码：89_0264410x
- 类别：imm
- 出版时间：17 March 2008
- 卷：26
- 期：12
- 页码：1525-1529
- 文件大小：345 K
摘要
Adjuvants enhance antibody response against vaccination. We compared the ability of MF59™-adjuvanted and non-adjuvanted subunit influenza vaccines, containing A/Wyoming/3/03(H3N2), to confer cross-protection against four consecutive drifted strains in the elderly. Neutralizing and haemagglutination-inhibiting antibody were measured. MF59™-adjuvanted vaccine induced a stronger booster response against A/Panama/2007/99(H3N2) than non-adjuvanted vaccine. A/Panama/2007/99(H3N2) circulated widely during the previous 5 years and was included in vaccines over four consecutive seasons. Broader serological protection against drifted strains that circulated 1 and 2 years after vaccination with A/Wyoming/3/03(H3N2) was observed with MF59™-adjuvanted vaccine. Thus, MF59™-adjuvanted vaccine confers greater immunogenicity than non-adjuvanted vaccines in vulnerable populations.