Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-脙脙脙脙

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• 作者：Martin ; Jennifer ; Kelly ; Darren J. ; Mifsud ; Sally A. ; Zhang ; Yuan ; Cox ; Alison J. ; See ; Fiona ; et. al.
• 关键词：Fibrosis ; Diabetes ; Growth factors ; Extracellular matrix
• 刊名：Cardiovascular Research
• 出版年：2005
• 期刊代码：48_00086363
• 类别：med
• 出版时间：February 15, 2005
• 卷：65
• 期：3
• 页码：694-701
• 文件大小：691 K

摘要

The pathological accumulation of extracellular matrix is a characteristic feature of diabetic cardiomyopathy that is directly related to a loss of function. Tranilast (n-[3,4-anthranilic acid), used for the treatment of fibrotic skin diseases, has also been shown to inhibit transforming growth factor-脦脦 (TGF-脦脦)-induced matrix production in kidney epithelial cells.