Module assemblage technology for floating systems: In vitro flotation and in vivo gastro-retention
- 作者：Orazio Luca Strusi ; Fabio Sonvico ; Ruggero Bettini ; Patrizia Santi ; Gaia Colombo ; Pedro Barata ; Ana Oliveira ; Delfim Santos ; Paolo Colombo
- 关键词：Release module ; Assembling technology ; Floating systems ; γ ; -scintigraphy ; Resultant-weight
- 刊名：Journal of Controlled Release
- 出版年：2008
- 期刊代码：25_01683659
- 类别：pha
- 出版时间：14 July 2008
- 卷：129
- 期：2
- 页码：88-92
- 文件大小：1484 K
摘要
The aim of this research was to study, in vitro by resultant-weight measurement and in vivo by γ-scintigraphy experiments in humans, the floatation behavior of systems obtained by modules assembled in void configuration. The assembled system technology allowed the manufacturing of a system characterized by the presence of an internal void space that provided an apparent density lower than water. The gastro-retention times of floating assembled systems were determined in comparison with non-floating systems having the same mass and composition. In vitro the floatation of the system started immediately after immersion in water and lasted for more than 5 h.