Effective protection induced by three different versions of the porcine S3Pvac anticysticercosis vaccine against rabbit experimental Taenia pisiformis cysticercosis

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• 作者：Miguel Angel Betancourtp>ap> ; Aline S. de Alujap>ap> ; Edda Sciuttop>bp> ; Marisela Herná ; ndezp>bp> ; Raú ; l J. Bobesp>bp> ; Gabriela Rosasp>cp> ; Beatriz Herná ; ndezp>dp> ; Gladis Fragosop>bp> ; Claudia Hallal-Callerosp>ep> ; Liliana Aguilarp>fp> ; Ivá ; n Flores-Peré ; zp>gp>p> ; p>p>ivanfloresperez@yahoo.com.mxp>
• 关键词：Taenia pisiformis ; Taenia solium ; S3Pvac ; Vaccination ; Cysticercosis ; Delivery system
• 刊名：Vaccine
• 出版年：2012
• 期刊代码：89_0264410x
• 类别：imm
• 出版时间：5 April, 2012
• 卷：30
• 期：17
• 页码：2760-2767
• 文件大小：1706 K

摘要

In an effort to develop an effective and affordable oral vaccine against porcine Taenia solium cysticercosis, the S3Pvac anti-cysticercosis vaccine was expressed in papaya calli. Taenia pisiformis experimental rabbit cysticercosis was used as a model to compare the efficacy of the oral vaccine vs. the injectable S3Pvac-synthetic and S3Pvac-phage versions.<p>Oral S3Pvac-papaya significantly reduced the expected number of hepatic lesions and peritoneal cysticerci to a similar extent than the injectable vaccines. This study reports for the first time an effective oral vaccine against T. pisiformis cysticercosis, possibly useful against porcine T. solium cysticercosis.