Effect of atorvastatin on plasma levels of asymmetric dimethylarginine in patients with non-ischaemic heart failure
- 作者：Joanna M. Young ; Christopher H. Strey ; Peter M. George ; Christopher M. Florkowski ; Christiaan W. Sies ; Christopher M. Frampton ; Russell S. Scott
- 关键词：Asymmetric dimethylarginine ; Left ventricular dysfunction ; Chronic heart failure ; Statin treatment ; Endothelial function
- 刊名：European Journal of Heart Failure
- 出版年：2008
- 期刊代码：90_13889842
- 类别：med
- 出版时间：May 2008
- 卷：10
- 期：5
- 页码：463-466
- 文件大小：149 K
摘要
Elevated plasma levels of asymmetric dimethylarginine (ADMA), an endothelial nitric oxide synthase (eNOS) inhibitor, may contribute to endothelial dysfunction in chronic heart failure (CHF). Since statins upregulate eNOS and ameliorate endothelial dysfunction in non-ischaemic CHF, we hypothesized that this may be in part through modification of ADMA.