Fluoride-containing bioactive glass-ceramics

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• 作者：D.S. Brauer^a ; ^{delia.brauer@uni-jena.de} ; M.N. Anjum^b ; M. Mneimne^a ; R.M. Wilson^b ; H. Doweidar^c ; R.G. Hill^a
• 关键词：Apatite ; Bioactive glass ; Biomedical applications ; Fluorapatite ; Fluoride
• 刊名：Journal of Non-Crystalline Solids
• 出版年：2012
• 期刊代码：50_00223093
• 类别：ms
• 出版时间：1 July, 2012
• 卷：358
• 期：12-13
• 页码：1438-1442
• 文件大小：608 K

摘要

Fluorapatite glass-ceramics are osteoconductive, and glass-ceramics containing fluorapatite crystals in a bioactive silicate glass matrix can combine the benefits of fluorapatite with the bone-regenerative properties of bioactive glasses. High phosphate content (around 6 mol%P₂O₅) bioactive glasses (SiO₂-P₂O₅-CaO-Na₂O-CaF₂) were prepared by a melt-quench route. Structural investigation using density measurements and calculations confirmed the presence of phosphorus as orthophosphate. Upon heat treatment, the glasses crystallised to mixed sodium calcium fluoride orthophosphates (sodium-containing compositions) and fluorapatite (sodium-free composition). Fluoride suppressed spontaneous crystallisation, allowing formation of glass-ceramics by controlled crystallisation. A notable feature is that silicate network polymerisation and network connectivity did not change during crystallisation, resulting in orthophosphate and fluorapatite crystals embedded within a bioactive glass matrix. By keeping the phosphate content high and the sodium content low, fluorapatite glass-ceramics can be obtained, while not affecting the structure of the bioactive silicate glass phase.