The 伪4尾2 nicotine acetylcholine receptor agonist ispronicline induces c-Fos expression in selective regions of the rat forebrain

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• 作者：Julie Jacobsen^a ; Henrik H. Hansen^b ; Alexander Kiss^c ; Jens D. Mikkelsen^a ; ^{jens_mikkelsen@dadlnet.dk}
• 关键词：Nicotine ; c-Fos ; Hypothalamo-pituitary adrenocortical axis ; Amygdala ; Rat
• 刊名：Neuroscience Letters
• 出版年：2012
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：25 April, 2012
• 卷：515
• 期：1
• 页码：7-11
• 文件大小：734 K

摘要

The dominant nicotine acetylcholine receptor (nAChR) subtype in the brain is the pentameric receptor containing both 伪4 and 尾2 subunits (伪4尾2). Due to the lack of selective agonists it has not been ruled out what neuronal circuits that are stimulated after systemic administration with nicotine. We used the novel and selective 伪4尾2 receptor agonist ispronicline (10 and 30 mg/kg s.c.) to localise the activated neurons in the rat forebrain using c-Fos-immunoreactivity as a marker of immediate neuronal activity. In the hypothalamic paraventricular nucleus, a large increase of c-Fos-positive cells was found only within its medial part. In addition, an increased number of c-Fos-immunoreactive cells were observed in the central nucleus of the amygdala, and the dorsolateral part of the bed nucleus of the stria terminalis. The restricted distribution of c-Fos to these areas, all of which are directly or indirectly involved in acute stress regulation after a single dose of ispronicline, supports earlier studies that the 伪4尾2 receptors are strongly involved in nicotine-dependent activation of the hypothalamo-pituitary adrenocortical axis.