Y-chromosomal microsatellite diversity in three culturally defined regions of historical Tibet

详细信息	查看全文 | 推荐本文 |

• 作者：Tenzin Gayden^a ; ^b ; ¹ ; Areej Bukhari^a ; ^b ; ¹ ; Shilpa Chennakrishnaiah^a ; ^c ; Oliver Stojkovic^d ; Rene J. Herrera^a ; ^{herrerar@fiu.edu}
• 关键词：Y-STR ; Yfiler ; Tibet ; U-Tsang ; Amdo ; Kham
• 刊名：Forensic Science International ; Genetics
• 出版年：2012
• 期刊代码：18_18724973
• 类别：bio
• 出版时间：July, 2012
• 卷：6
• 期：4
• 页码：437-446
• 文件大小：288 K

摘要

In the present study, we analyzed 17 Y-STR loci in 350 Tibetan males from three culturally defined regions of historical Tibet: Amdo (88), Kham (109) and U-Tsang (153). A total of 299 haplotypes were observed, 272 (90.9%) of which were unique. Only one Y-STR profile is shared across the three Tibetan groups and, incidentally, is also the most frequent haplotype (4.0%), represented by two, five and seven individuals from U-Tsang, Kham and Amdo, respectively. The overall haplotype diversity for the three Tibetan populations at 17 Y-STR loci was 0.9978 and the corresponding values for the extended (11-loci) and minimal (9-loci) haplotypes were 0.9935 and 0.9909, respectively. Both neighbor-joining and Rst pairwise analyses suggest a close genetic relationship between the Amdo and Kham populations, while U-Tsang is genetically distinct from the aforementioned groups. The results demonstrate that the 17 Y-STR loci analyzed are highly polymorphic in all three Tibetan populations examined and hence useful for forensic cases, paternity testing and population genetic studies.