Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase
- 作者：Youn-Hi Woo ; Roberta P.M. Fernandes and Philip J. Proteau
- 关键词：Isoprenoid biosynthesis ; Fosmidomycin ; Reductoisomerase ; Methylerythritol phosphate pathway
- 刊名：Bioorganic and Medicinal Chemistry
- 出版年：2006
- 期刊代码：9_09680896
- 类别：ch
- 出版时间：1 April 2006
- 卷：14
- 期：7
- 页码：2375-2385
- 文件大小：213 K
摘要
Analogs of the antibiotic fosmidomycin, an inhibitor of the methylerythritol phosphate pathway to isoprenoids, were synthesized and evaluated against the recombinant Synechocystis sp. PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR). Fosfoxacin, the phosphate analog of fosmidomycin, and its acetyl congener were found to be more potent inhibitors of DXR than fosmidomycin.