Utilidad del 谩cido docosahexaenoico en el tratamiento de la infertilidad masculina

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• 作者：Juan G. Á ; lvarez^a ; ^b ; ^{jalvarez@androgen.es}
• 关键词：Necrozoospermia ; Í ; ndice de fragmentaci&oacute ; n de ADN ; Test TUNEL ; Á ; cido docosahexaenoico
• 刊名：Revista Internacional de Androlog铆a
• 出版年：2011
• 期刊代码：pca322_1698031X
• 类别：med
• 出版时间：October-December 2011
• 卷：9
• 期：4
• 页码：138-144
• 文件大小：219 K

摘要

Introduction and objectives

Previous studies have shown that the membrane and desoxiribonucleic acid (DNA) damage observed in ejaculated spermatozoa is mostly produced post-testicularly, during passage of sperm through the epididymis. This damage is induced, for the most part, by free radicals and amplified by proinflammatory factors. The objective of this study was to evaluate the efficacy and safety of docosahexaenoic acid (DHA), a longchain polyunsaturated fatty acid with anti-inflammatory and antioxidant properties, in the treatment of male infertility associated to sperm membrane and DNA damage.

Material and methods

A total of 80 patients diagnosed of necrozoospermia, measured as sperm viability, or of an abnormal sperm DNA fragmentation index (DFI), measured by the TUNEL test, were included in the study. In the necrozoospermia group, as well as in the abnormal DNA fragmentation (DFI > 20%) group, 20 patients were included in the experimental group treated with 200 mg of DHA derived from the microalgae Schizochytrium sp. (GestaDha^庐) (patent by Martek Bioscience Corporation under registered trademark life's DHA鈩? every 12 hours, and 20 patients were included in the control group not treated. The duration of the treatment was of 8 weeks and semen samples were obtained at 0, 1, 2, 4 y 8 weeks of treatment for the analysis of sperm viability and the DFI.

Results

The data showed that GestaDha^庐 significantly decreased both the rate of necrozoospermia and the DFI after the first week of treatment compared to the control group. Differences between the experimental and control groups were statistically significant for both parameters (p < 0.01). No adverse effects were observed in any of the patients treated with GestaDha^庐.

Conclusions

This study shows, for the first time, the efficacy and safety of GestaDha^庐 in the treatment of male infertility associated to sperm membrane and DNA damage.