Prehypertension among adults in Great Tunis region (Tunisia): A population-based study

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• 作者：M. Allal-Elasmi^a ; ^{monia_elasmi@yahoo.fr} ; M. Feki^a ; Y. Zayani^a ; M. Hsairi^b ; S. Haj Taieb^a ; R. Jemaa^a ; H. Sanhaji^a ; S. Omar^a ; A. Mebazaa^a ; N. Kaabachi^a
• 关键词：Coronary heart disease ; Framingham risk score ; Hypertension ; Obesity ; Prehypertension
• 刊名：Pathologie Biologie
• 出版年：2012
• 期刊代码：216_03698114
• 类别：med
• 出版时间：June, 2012
• 卷：60
• 期：3
• 页码：174-179
• 文件大小：522 K

摘要

Purpose

The present study aimed to determine the prevalence of prehypertension (preHTN) and its cardiometabolic profile in Tunisians, and to estimate the risk for coronary heart disease (CHD) according to blood pressure status.

Patients and method

This cross-sectional study was conducted in 2004-2005, and used a two-stage cluster sampling method to select a representative sample of the Great Tunis population. A total of 2712聽individuals (1228 men and 1484 women), aged 35聽to 69聽years were included. Definition and classification of hypertension (HTN) was performed according to guidelines from the Joint National Committee on prevention, detection, evaluation and treatment of high blood pressure (JNC-7) report.

Results

The prevalence of preHTN and HTN was 56.8%and 25.0%in males, and 43.1%and 36.1%in females, respectively. Subjects with preHTN and those with HTN showed higher prevalence of diabetes, dyslipidemia, obesity and abdominal obesity than the normotensive (NT) group. The metabolic syndrome (MetS) was found in 8.0%, 17.8%and 53.8%of NT, preHT and HTN subjects, respectively. The risk of developing CHD within 10聽years, as predicted by the Framingham-Anderson model, was above 15%for 3.9%, 31.1%and 65.0%among NT, preHTN and HTN subjects, respectively. In multivariate analysis, preHTN was associated with age (OR [95%CI], 1.02 [1.01-1.03]; P < 0.01), male gender (2.51 [1.89-3.23]; P < 0.001), obesity (2.36 [1.71-3.26]; P < 0.01), abdominal obesity (1.53 [1.14-2.06]; P < 0.01) and smoking (0.70 [0.53-0.92]; P < 0.01).

Conclusion

PreHTN is very common in Tunisians. It is associated with a higher prevalence of cardiometabolic risk factors and confers a higher risk for subsequent CHD. These findings support the recommendations of lifestyle modification for preHTN patients.