Current knowledge and key points. x2013; Diseases with a clinical profile close to here
ditary angioneurotic e
dema, but without C1Inh anomaly, have been
describe
d recently. It is in fact family cases, concerning only women, where estrogens seem to play a
dominant role. Angioe
dema
x2019;s secon
dary aspects are gathering various pathologies (vasculitis, Gleich
x2019;s syn
drome, angioe
dema initiate
d by physical agents). The role playe
d by some
drugs must not be forgotten, mainly angiotensin converting enzyme inhibitors, which are at the origin of angio
dema in nearly 0.5%of users.
Future prospect and projects. x2013; Uncontrolled activation of the contact system seems to play a major role in the main part of these angiodemas. The efficiency of the tranexaminic acid (which modulates its activation) is to be taken as evident. The key to the future seems to be the development of plasmin and bradykinin inhibitors.div>div>
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Les angiœdème héréditaires de type III : nouvelle maladie ou nouveau diagnostic ?