- 作者：Alberto Vá ; zquez Rodrí ; guez ; albvaz@dexeus.com ; Rosa Tur Padró ; Francisca Martí ; nez San André ; s ; Laura Mateo Ló ; pez ; Buenaventura Coroleu Lletget ; Carmina Comas Gabriel ; Pedro Nolasco Barri Ragué
- 关键词：Gestació ; n y edad avanzada ; Té ; cnicas de reproducció ; n asistida y resultados perinatales
- 刊名：Progresos de Obstetricia y Ginecolog铆a
- 出版年：2010
- 期刊代码：pca294_03045013
- 类别：med
- 出版时间：October 2010
- 卷：53
- 期：10
- 页码：391-398
- 文件大小：226 K
class="h4">Objective
To evaluate the influence of age 鈮?40 years and ART in our obstetric and perinatal outcomes.
class="h4">Material and methods
Retrospective study of 14805 singleton pregnancies in our Institute from January 1, 2000 to December 31, 2006. We compared obstetric and perinatal outcome between: Age group: women 鈮?40 years (N = 557) vs. group of women < 40 years (N = 14248); ART group < 40 years: ART pregnancies (N = 1150) vs. spontaneous pregnancies (N = 13098); ART group 鈮?40 years: ART pregnancies (N = 126) vs. spontaneous pregnancies (N = 431).
Results: Age 鈮?40 years is significantly associated with preterm birth under 34 weeks (odds ratio [OR] = 2.148 [1.237-3.730]), gestational diabetes (OR = 2.25 [1.799-2.815]), placenta previa (OR = 3.346 [1.516-7.386]), caesarean delivery (OR = 1.831 [1.539-2.177]), and peripartum hysterectomy (OR = 6.414 [1.359-2.177]). In the ART group < 40 years assisted conception (ART) is significantly associated with preterm birth under 37 (OR = 1.67 [1.337-2.088]) and 34 weeks (OR = 1.8 [1.162-2.822]), with gestational diabetes (OR = 1.5 [1.273-1.844]), pre-eclampsia (OR = 2.1 [1.456-3.164]), placenta previa (OR = 5.29 [2.973-9.437]), choriamniotic infection (OR = 3.8 [1.029-14.072]), caesarean delivery (OR = 1.5 [1.346-1.737]) and low birth weight 鈮?2500 g. (OR = 1.67 [1.329-2.114]) and 鈮?1500 g. (OR = 2.44 [1.442-4.135]). In the ART group 鈮?40 years we only find a significantly increased rate of caesarean delivery (OR = 1.76 [1.183-2.635]) in ART group vs. spontaneous pregnancy group.
class="h4">Conclusions
Age 鈮?40 years increases the risk of adverse obstetric outcome. ART increase the risk of adverse obstetric and perinatal outcome in the group < 40 years, but not in the group of women aged 40 years and older, probably due to the small size of the sample.