Anticonvulsant effects of agomelatine in mice

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• 作者：Carlos Clayton Torres Aguiar^a ; Aná ; lia Barbosa Almeida^b ; ¹ ; Paulo Victor Pontes Araú ; jo^b ; ¹ ; Germana Silva Vasconcelos^b ; ¹ ; Edna Maria Camelo Chaves^b ; ¹ ; Otoni Cardoso do Vale^b ; ¹ ; Danielle Silveira Macê ; do^b ; ¹ ; Francisca Cl&eacute ; a Florenç ; o de Sousa^b ; ¹ ; Glauce Socorro de Barros Viana^b ; ¹ ; Silvâ ; nia Maria Mendes Vasconcelos^b ; ^{silvania@pesquisador.cnpq.br} ; ^{silvania_vasconcelos@yahoo.com.br}
• 关键词：Agomelatine ; Strychnine ; Pilocarpine ; Electroshock stimulation ; Anticonvulsant effect ; Picrotoxin ; Seizure ; Melatonin
• 刊名：Epilepsy & Behavior
• 出版年：2012
• 期刊代码：76_15255050
• 类别：neu
• 出版时间：July, 2012
• 卷：24
• 期：3
• 页码：324-328
• 文件大小：167 K

摘要

Agomelatine is a potent MT1 and MT2 melatonin receptor agonist and a 5-HT2C serotonin receptor antagonist. We analyzed whether agomelatine has anticonvulsant properties. The anticonvulsant activity of agomelatine (25, 50 or 75 mg/kg, i.p.) was evaluated in mouse models of pentylenetetrazole (PTZ-85 mg/kg, i.p.), pilocarpine (400 mg/kg, i.p.), picrotoxin (7 mg/kg, i.p.), strychnine (75 mg/kg, i.p.) or electroshock-induced convulsions. In the PTZ-induced seizure model, agomelatine (at 25 or 50 mg/kg) showed a significant increase in latency to convulsion, and agomelatine (at 50 or 75 mg/kg) also increased significantly time until death. In the pilocarpine-induced seizure model, only agomelatine in high doses (75 mg/kg) showed a significant increase in latency to convulsions and in time until death. In the strychnine鈥? electroshock鈥?and picrotoxin-induced seizure models, agomelatine caused no significant alterations in latency to convulsions and in time until death when compared to controls. Our results suggest that agomelatine has anticonvulsant activity shown in PTZ鈥?or pilocarpine-induced seizure models.