Dolomitic and quartz itabirites have a very simple chemical composition. In the dolomitic itabirite, Fe2O3 plus CaO, MgO, and LOI range from 95.8 to 97.8%, while in the quartz itabirite, Fe2O3 plus SiO2 range from 94.4 to 99.6%. Both itabirites are highly oxidized and present Fe3+/(Fe2+ + Fe3+) ratios higher than 0.98, by far superior than the average ratios of Paleoproterozoic BIFs. Trace element concentrations in itabirites are very low, ranging from <10 to 55 ppm. Dolomite shows negative δ13C values varying from −2.5 to −0.8‰ versus PDB, while the oxygen isotope data display δ18O values varying from −12.4 to −8.5‰ versus PDB. The δ13C values of the dolomitic itabirite are in the same range of those of the overlying stromatolitic dolomites of the Gandarela Formation. C and O isotopes, REE signatures, and Y/Ho ratios suggest a marine origin for the sediments of the Cauxea; Formation. The HREE enrichment pattern exhibited by the itabirites shows a modern seawater REE signature overprinted by a hydrothermal pattern marked by positive Eu anomalies. Very low contents of Al2O3 and TiO2 and a strong positive correlation between them indicate a minor terrigenous component in the chemically-precipitated marine sediments of the Cauxea; Formation. Differences in the HREE signatures of itabirites suggest that dolomitic itabirite precipitated in shallower waters receiving sediments from the continent, while quartz itabirite precipitated in deeper waters. Sea-level fluctuations caused by marine transgression–regressions possibly contributed to changes in the composition and varied input of the terrigenous sediments. These changes are expressed by the co-existence of dolomitic, quartz, and amphibolitic itabirites in the Cauxea; Formation, which represent lateral and vertical facies transitions of dolomitic, cherty, and shaly BIFs, respectively.