Ethnic differences in the clinical presentation of Graves鈥?ophthalmopathy

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• 作者：Chiaw-Ling Chng ; MBBS ; MRCP^a ; ^{chng.chiaw.ling@sgh.com.sg} (Associate Consultant Endocrinologist) ; Lay Leng Seah ; MBBS ; FRCS(Ed) ; FRCOphth ; FAMS^b ; ^{seah.lay.leng@snec.com.sg} (Senior Consultant Ophthalmologist ; Associate Professor of Ophthalmology) ; Daphne Hsu Chin Khoo ; MBBS ; MMed (Int Med) ; FAMS ; FRCP^a ; ^{geckhs@sgh.com.sg} (Senior Consultant Endocrinologist ; Associate Professor of Medicine)
• 关键词：Graves&rsquo ; ophthalmopathy ; Graves&rsquo ; disease ; ethnicity
• 刊名：Best Practice Research Clinical Endocrinology Metabolism
• 出版年：2012
• 期刊代码：34_1521690X
• 类别：med
• 出版时间：June, 2012
• 卷：26
• 期：3
• 页码：249-258
• 文件大小：166 K

摘要

Ethnic differences in a number of eye conditions have been described. The literature on ethnic differences in Graves鈥?ophthalmopathy (GO) is limited. There is some evidence to suggest Asian patients with GO may manifest milder phenotypic features of GO, with less proptosis and evidence of extraocular muscle involvement and restriction. The reasons for these differences are likely to be multifactorial and include orbital and lid anatomy, genetic background and autoimmune responses including TSH -receptor antibodies. These differences should be kept in mind when evaluating and managing patients with GO.