APOE and modulation of Alzheimer's and frontotemporal dementia
- 作者：Boccardi ; M. ; Sabattoli ; F. ; Testa ; C. ; Beltramello ; A. ; Soininen ; H. ; Frisoni ; G.B.
- 关键词：Dementia ; APOE ; AD ; Frontotemporal dementia ; Imaging ; Morphology ; MR ; Voxel based morphometry
- 刊名：Neuroscience Letters
- 出版年：2004
- 期刊代码：52_03043940
- 类别：neu
- 出版时间：February 19, 2004
- 卷：356
- 期：3
- 页码：167-170
- 文件大小：114 K
摘要
To investigate the difference in the morphologic expression of frontotemporal dementia (FTD) and Alzheimer's disease (AD) in patients carrying and not carrying the g align=center border=0 SRC=/images/glyphs/CDE.GIF>4 allele of APOE, MR images of 26 controls, 18 AD patients (11 carrying the g align=center border=0 SRC=/images/glyphs/CDE.GIF>4 allele, seven non-carriers), and eight FTD (two carriers, six non-carriers) were compared using voxel by voxel analysis. Greater atrophy was found in the disease-specific regions of the g align=center border=0 SRC=/images/glyphs/CDE.GIF>4 carriers vs the non-carriers at P<0.05 corrected: medial temporal atrophy was greater in the AD carrying the g align=center border=0 SRC=/images/glyphs/CDE.GIF>4 allele, right ventral striatal atrophy in the FTD carrying the allele. The non-carriers did not have atrophic regions compared to the carriers. The g align=center border=0 SRC=/images/glyphs/CDE.GIF>4 allele of the APOE might modulate the expression of degenerative dementias by enhancing the specific effects of neurodegenerative diseases on the brain.