Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter

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• 作者：Marina Boccardi ; Catia Scassellati ; Roberta Ghidoni ; Cristina Testa ; Luisa Benussi ; Matteo Bonetti ; Luisella Bocchio-Chiavetto ; Massimo Gennarelli ; Giuliano Binetti ; Giovanni B. Frisoni
• 关键词：Estrogen receptor alpha ; XbaI ; Neuroimaging ; MR ; VBM ; Morphometry
• 刊名：Neuroscience Letters
• 出版年：2008
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：4 April 2008
• 卷：434
• 期：3
• 页码：304-309
• 文件大小：372 K

摘要

The frequent polymorphism XbaI (A351G) in the estrogen receptor alpha (ERalpha) gene has been associated with some postmenopausal pathologies’ risk such as Alzheimer's disease (AD) or cognitive decline. In the present study, we explored whether the XbaI polymorphism leads to different gray matter volumes using voxel-based morphometry (VBM) on 20 magnetic resonance images of healthy postmenopausal women. Subjects carrying the less common XbaI/X allele were contrasted to non-carriers in groups well balanced by relevant confounding variables. The XbaI/X allele carriers displayed clusters ranging from 9 to 28%of tissue reductions in the cerebellar (cluster size, z, stereotactic coordinates: 16 mm³; 3.17; 14, −94, −38) and cerebral cortex, in particular in the occipital lobe (272 mm³; 3.76; −38,−68,−16), in the middle frontal gyrus (192 mm³; 3.71; 38, 12, 38) and in the middle temporal gyrus, while the opposite comparison was negative. The XbaI/X allele in ERalpha gene is associated to smaller gray matter volumes of the cerebral and cerebellar cortex. This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve.