A concise synthesis of tetrahydroisoquinoline-1-carboxylic acids using a Petasis reaction and Pomeranz-Fritsch-Bobbitt cyclization sequence
- 作者：Maria Chrzanowska ; Agnieszka Grajewska ; Zofia Meissner ; Maria Rozwadowska ; mdroz@amu.edu.pl ; Iwona Wiatrowska
- 关键词：Tetrahydroisoquinoline-1-carboxylic acids ; Petasis reaction ; Pomeranz&ndash ; Fritsch&ndash ; Bobbitt cyclization
- 刊名：Tetrahedron
- 出版年：2012
- 期刊代码：107_00404020
- 类别：ch
- 出版时间：8 April, 2012
- 卷：68
- 期：14
- 页码：3092-3097
- 文件大小：1533 K
摘要
A sequence of two reactions: the Petasis reaction, in which an aminoacetaldehyde acetal was used as the amine component, followed by Pomeranz-Fritsch-Bobbitt cyclization, has been shown to be a convenient and simple method for the synthesis of tetrahydroisoquinoline-1-carboxylic acids. Using this method several acids have been prepared in good to excellent yields and characterized as hydrochloride salts.