Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein

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• 作者：Vitozzi ; Susana ; Lapierre ; Pascal ; Djilali-Saiah ; Idriss ; Alvarez ; Fernando
• 关键词：Type 2 autoimmune hepatitis ; CYP2D6 ; LKM1 ; FTCD ; LC1 ; ELISA ; Autoantibodies ; aa ; amino acid ; AIH ; autoimmune hepatitis ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; bp ; base pair ; CYP2D6 ; P450 2D subfamily ; FTCD ; formiminotransferase cy
• 刊名：Journal of Immunological Methods
• 出版年：2002
• 期刊代码：57_00221759
• 类别：imm
• 出版时间：April 1, 2002
• 卷：262
• 期：1-2
• 页码：103-110
• 文件大小：110 K

摘要

Autoantibodies against cytochrome P450 2D6 (CYP2D6), known as anti-liver/kidney microsome type 1 (LKM1) and/or anti-human formiminotransferase cyclodeaminase, formally known as anti-liver cytosol type 1 (LC1) define type 2 autoimmune hepatitis (AIH). The aims of this work are to develop a sensitive and specific test to detect anti-LKM1 and/or anti-LC1 autoantibodies and to establish the prevalence of anti-LC1. Sera from children with type 2 AIH (n