Synthesis of xestobergsterol A from dehydroepiandrosterone

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• 作者：Atsuko Nakamura ; Yuko Kaji ; Kana Saida ; Michiko Ito ; Yumi Nagatoshi ; Noriyuki Hara and Yoshinori Fujimoto
• 关键词：Xestobergsterol A ; Steroid ; Dehydroepiandrosterone ; Orthoester Claisen rearrangement
• 刊名：Tetrahedron Letters
• 出版年：2005
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：2005
• 卷：46
• 期：37
• 页码：6373-6376
• 文件大小：124 K

摘要

Xestobergsterol A, a potent inhibitor of histamine release, has been synthesized from dehydroepiandrosterone in a route that used introduction of a novel 15-oxygen functionality, side-chain construction via the orthoester Claisen rearrangement and TBAF-promoted epimerization–aldol condensation.