Activin and inhibin, estrogens and NF魏B, play roles in ovarian tumourigenesis is there crosstalk?
- 作者：Ann E. Drummond ; ann.drummond@princehenrys.org ; Peter J. Fuller
- 关键词：Ovarian cancer ; Estrogen ; TGF-尾 ; NF魏B
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2012
- 期刊代码：109_03037207
- 类别：bio
- 出版时间：15 August, 2012
- 卷：359
- 期：1-2
- 页码：85-91
- 文件大小：404 K
摘要
Ovarian cancer may be the most frequently lethal gynaecological malignancy but the heterogeneous nature of the disease and the advanced stage at which it is usually diagnosed, have contributed to the paucity of information relating to its aetiology and pathogenesis. Members of the TGF-尾 superfamily, estrogen and NF魏B have all been implicated in the development and progression of cancers from a wide range of tissues. In the ovary, TGF-尾 superfamily members and estrogen play key roles in maintaining normal function. To date, little is known about the capacity of NF魏B to influence normal ovarian function except that it is ubiquitously expressed. In this review we will highlight the roles that inhibin/activin, estrogen and NF魏B, have been attributed within carcinogenesis and examine the potential for crosstalk between these pathways in ovarian cancer pathogenesis.