Impact of smoking cessation on incidence of diabetes mellitus among overweight or normal-weight Japanese men

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• 作者：Akiko Morimoto^a ; ^b ; ^{aki62@belle.shiga-med.ac.jp} ; Yuko Ohno^a ; Yukako Tatsumi^a ; Yoshio Nishigaki^c ; Fumio Maejima^c ; Shoichi Mizuno^d ; Shaw Watanabe^e
• 关键词：Smoking cessation ; Overweight ; Normal weight
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2012
• 期刊代码：78_01688227
• 类别：med
• 出版时间：June, 2012
• 卷：96
• 期：3
• 页码：407-413
• 文件大小：155 K

摘要

Aims

To assess the impact of smoking cessation on incidence of diabetes among overweight or normal-weight Japanese men.

Methods

This 9.2-year cohort study included 2070 men aged 40-69 years without diabetes. We classified them according to smoking status as non-smokers, past smokers (>9, 6-9, 3-5 and <3 years) and current smokers. Participants were followed up until diabetes developed or the end of 2006. The incidence of diabetes was determined from fasting and random plasma glucose levels, HbA_1c levels or being under medical treatment for diabetes.

Results

During 18,963 person-years of follow-up, 246 of the participants developed diabetes. The risk for diabetes peaked within 3 years of quitting (HR: 2.98, 95%CI: 1.38-6.27) and persisted at 5 years after quitting smoking (HR, 2.49; 95%CI, 1.18-5.26) among overweight individuals. Moreover, this study identified a high risk for diabetes among past smokers who had quit >9 years in both normal weight and overweight.

Conclusions

Cigarette smoking predicts incidence of diabetes, but smoking cessation leads to higher short-term risk in overweight and long-term risk in both. Preventing smoking is superior to smoking cessation, and is very important for avoiding diabetes.