Concise syntheses of immunostimulating glycolipids, α-galactosyl ceramides

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• 作者：Takashi Tsujimoto ; Yukishige Ito
• 关键词：Calix-arenes ; Acylation ; Amphiphilic ; Langmuir ; Monolayer
• 刊名：Tetrahedron Letters
• 出版年：2007
• 期刊代码：109_00404039
• 类别：ch
• 出版时间：30 July 2007
• 卷：48
• 期：31
• 页码：5513-5516
• 文件大小：188 K

摘要

α-Galactosylceramides (α-GalCers) are well known as immunostimulating agents having therapeutic potential. To facilitate the synthesis of α-GalCers and their derivatives, a novel and convergent strategy was designed, which is expected to be versatile for the preparation of a variety of analogues in a diversity-oriented fashion. As an initial demonstration of our strategy, KRN7000 and OCH were synthesized in eight steps from a common intermediate, which is easily obtainable in a multi-gram scale.