Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric 伪-galactosyl ceramide analogues

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• 作者：Peter J. Jervis^a ; Marie Moulis^b ; John-Paul Jukes^c ; Hemza Ghadbane^c ; Liam R. Cox^b ; Vincenzo Cerundolo^c ; Gurdyal S. Besra^a ; ^{g.besra@bham.ac.uk}
• 关键词：伪-GalCer ; Dimer ; Multivalency ; CD1d ; iNKT cells ; Click chemistry
• 刊名：Carbohydrate Research
• 出版年：2012
• 期刊代码：15_00086215
• 类别：ch
• 出版时间：15 July, 2012
• 卷：356
• 期：Complete
• 页码：152-162
• 文件大小：1255 K

摘要

A library of dimeric CD1d ligands, containing two 伪-galactosyl ceramide (伪-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6鈥?azido-6鈥?deoxy-伪-galactosyl ceramide derivative and various diynes. Each 伪-GalCer dimer was tested for its ability to stimulate iNKT cells.