Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt–Jakob disease

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• 作者：Sashank Prasad ; Melissa W. Ko ; Edward B. Lee ; Nicholas K. Gonatas ; Matthew B. Stern ; Steven Galetta
• 关键词：Creutzfeldt– ; Jakob disease ; Prion ; Progressive supranuclear palsy ; Ophthalmoplegia
• 刊名：Journal of the Neurological Sciences
• 出版年：2007
• 期刊代码：178_0022510x
• 类别：med
• 出版时间：15 February 2007
• 卷：253
• 期：1-2
• 页码：69-72
• 文件大小：443 K

摘要

Supranuclear gaze palsies are an uncommon feature of Creutzfeldt–Jakob disease (CJD). Most reported cases of CJD with features of supranuclear gaze palsy are familial. We report 2 patients with supranuclear vertical gaze abnormalities associated with spongiform changes in the midbrain. Both patients were found to have sporadic CJD after genetic testing. Distinguishing familial from sporadic CJD in this setting has important genetic and epidemiological implications.