Plasma level of calcitonin gene-related peptide in patients with polycystic ovary syndrome and its relationship to hormonal and metabolic parameters

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• 作者：Zhe Zhang ; Fei Gong ; Guang-Xiu Lu ; ^{lugxdirector@yahoo.com.cn}
• 关键词：Calcitonin gene-related peptide (CGRP) ; Insulin resistance (IR) ; Polycystic ovary syndrome (PCOS) ; Testosterone (T)
• 刊名：Peptides
• 出版年：2012
• 期刊代码：59_01969781
• 类别：neu
• 出版时间：April, 2012
• 卷：34
• 期：2
• 页码：343-348
• 文件大小：412 K

摘要

The aim of the study was to evaluate the plasma level of calcitonin gene-related peptide (CGRP) in patients with polycystic ovary syndrome (PCOS) and its relationship to hormonal and metabolic parameters. We also observed the effect of CGRP on testosterone (T) and estradiol (E₂) release in cultured human granulosa cells. PCOS subjects (n = 215) and matched healthy control women (n = 103) at age of 22-38 years were enrolled in this study. We analyzed plasma CGRP concentrations, relationship of plasma CGRP with insulin resistance (IR), body mass index (BMI), luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio and T. The T and E₂ release levels of cultured human granulosa cells treated by CGRP were also measured. The results showed that plasma CGRP concentrations were significantly higher in women with PCOS than those of control subjects. In women with PCOS, there was a strong positive correlation between the plasma CGRP level with HOMA-IR, AUC-insulin, AUC-glucose, the ratio of LH/FSH and plasma T concentration. Human granulosa cells expressed CGRP receptor. Exogenous CGRP caused an elevation of T and E₂ released from the human granulosa cells. These findings suggest that CGRP may participate in the pathophysiological process of PCOS.