The effect of HMG-CoA reductase inhibitors on naturally occurring CD4⁺CD25⁺ T cells

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• 作者：Karin Mausner-Fainberg ; Galia Luboshits ; Adi Mor ; Sophia Maysel-Auslender ; Ardon Rubinstein ; Gad Keren ; Jacob George
• 关键词：Statins ; Atherosclerosis ; T cells ; Immune response ; Foxp3
• 刊名：Atherosclerosis
• 出版年：2008
• 期刊代码：28_00219150
• 类别：med
• 出版时间：April 2008
• 卷：197
• 期：2
• 页码：829-839
• 文件大小：1400 K

摘要

Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) are in widespread use due to their LDL reducing properties and concomitant improvement of clinical outcome in patients with and without preexisting atherosclerosis. Considerable evidence suggests that immune mediated mechanisms play a dominant role in the beneficial effects of statins. Naturally occurring CD4⁺CD25⁺ regulatory T cells (Tregs) have a key role in the prevention of various inflammatory and autoimmune disorders by suppressing immune responses. We tested the hypothesis that statins influence the circulating number and the functional properties of Tregs.