Diacylglycerol Activation of Protein Kinase C蔚 and Hepatic Insulin Resistance

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• 作者：Franç ; ois&#160 ; R. Jornayvaz¹ ; Gerald&#160 ; I. Shulman¹ ; ² ; ³ ; ^{gerald.shulman@yale.edu}
• 刊名：Cell Metabolism
• 出版年：2012
• 期刊代码：46_15504131
• 类别：med
• 出版时间：2 May, 2012
• 卷：15
• 期：5
• 页码：574-584
• 文件大小：875 K

摘要

Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in Western societies, affecting one in four adults in the USA, and is strongly associated with hepatic insulin resistance, a major risk factor in the pathogenesis of type 2 diabetes. Although the cellular mechanisms underlying this relationship are unknown, hepatic accumulation of diacylglycerol (DAG) in both animals and humans has been linked to聽hepatic insulin resistance. In this Perspective, we discuss the role of DAG activation of protein kinase C蔚 as the mechanism responsible for NAFLD-associated hepatic insulin resistance seen in obesity, type 2 diabetes, and lipodystrophy.