5-HT_2A SNPs and the Temperament and Character Inventory

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• 作者：Aless ; ro Serretti ; Raffaella Calati ; Ina Giegling ; Annette M. Hartmann ; Hans-Jü ; rgen Mö ; ller ; Cristina Colombo ; Dan Rujescu
• 关键词：5-HT_2A ; Character ; Personality ; TCI ; Temperament
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：2007
• 期刊代码：222_02785846
• 类别：med
• 出版时间：15 August 2007
• 卷：31
• 期：6
• 页码：1275-1281
• 文件大小：217 K

摘要

Temperamental traits, the most basic part of personality, have been largely correlated with neurotransmitter systems and are under genetic control. Among serotonin candidates, the 2A receptor (5-HT_2A) received considerable attention. We analyzed four SNPs (rs643627, rs594242, rs6311 and rs6313) in the 5-HT_2A gene and their association with personality traits, as measured with the Temperament and Character Inventory (TCI). The sample was composed of three sub-groups: two German sub-samples, consisting of a healthy group of 289 subjects (42.6%males, mean age: 45.2 ± 14.9) and a psychiatric patient group of 111 suicide attempters (38.7%males, mean age: 39.2 ± 13.6), and an Italian sub-sample, composed of 60 mood disorder patients (35.0%males, mean age: 44.0 ± 14.8). Controlling for sex, age and educational level, the SNPs were not strongly associated with personality dimensions. Only the rs594242 showed an association with Self-Directedness (p = 0.003) in the German sample, while rs6313 was marginally associated with Novelty Seeking (p = 0.01) in the Italian sample. We conclude that 5-HT_2A SNPs may marginally modulate personality traits but further studies are required.