Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers
- 作者：Georg Juckel ; Ulrich Hegerl ; Ina Giegling ; Paraskevi Mavrogiorgou ; Jü ; rgen Gallinat ; Holger Augustin ; Christoph Mulert ; Oliver Pogarell ; Dan Rujescu
- 关键词：Loudness dependence ; Auditory evoked potentials ; Serotonin transporter ; Polymorphism ; Community-based sample ; Haplotypic analysis
- 刊名：Psychiatry Research
- 出版年：2007
- 期刊代码：225_01651781
- 类别：med
- 出版时间：31 October 2007
- 卷：153
- 期：2
- 页码：183-187
- 文件大小：195 K
摘要
Three previous studies found an association between the loudness dependence (LD) of the auditory evoked potential N1/P2 component, an indicator of central serotonergic neurotransmission, and a functional variation in the promoter region of the 5-hydroxytryptamine transporter (5-HTT) gene (rs4795541 Ins/Del). The results of these three studies were contradictory and possibly biased by the recruitment methods used. We therefore aimed to re-investigate this association (rs4795541) using a community-based sample randomly selected from the general population and to extend the analysis to four further putative variations in this gene (rs3783594, rs3794808, rs140701, rs6354). In this carefully recruited sample, genotypes or haplotypes under investigation were not associated with LD. We speculate that the LD endophenotype depends more on genetic variations in components of the serotonergic system controlling release than on those controlling the uptake mechanism.