Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis
- 作者：Rujescu ; Dan ; Giegling ; Ina ; Sato ; Tetsuya ; Hartmann ; Annette M. ; Mö ; ller ; Hans-Jü ; rgen
- 关键词：Suicide ; gene ; polymorphism ; single-nucleotide polymorphism ; tryptophan hydroxylase
- 刊名：Biological Psychiatry
- 出版年：2003
- 期刊代码：34_00063223
- 类别：med
- 出版时间：August 15, 2003
- 卷：54
- 期：4
- 页码：465-473
- 文件大小：97.9 K
摘要
Neurobiological studies implicate serotonergic dysfunction in suicidal behavior. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin, plays a vital role in serotonin metabolism. Thus, variations in the TPH gene have been regarded as prime candidates in the susceptibility to suicidal behavior. The most widely studied genetic variations in the TPH gene, which are located in intron 7, yielded conflicting results in individual studies on suicide-related behavior.