Inhibition of inflammations and macrophage activation by ginsenoside-Re isolated from Korean ginseng (Panax ginseng C.A. Meyer)

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• 作者：Souren Paul^a ; Heung Sop Shin^b ; Sun Chul Kang^a ; ^{sckang@daegu.ac.kr}
• 关键词：Anti-inflammatory activity ; Saponins ; BALB/c mice ; Cytokines ; Raw 264.7 macrophage
• 刊名：Food and Chemical Toxicology
• 出版年：2012
• 期刊代码：20_02786915
• 类别：pha
• 出版时间：May, 2012
• 卷：50
• 期：5
• 页码：1354-1361
• 文件大小：1078 K

摘要

This study was undertaken to evaluate the effect of ginsenoside-Re (Gin-Re) isolated from roots of Panax ginseng on carrageenan-induced paw and TPA-induced skin inflammations in experimental mice. Moreover, to confirm further the anti-inflammatory activities of Gin-Re, LPS-induced macrophage activation model was also used. Exposure of TPA on the ear of BALB/c mice caused a marked increase in both ear thickness and skin water content. Gin-Re caused significant decrease in ear thickness and subsequently reduced the water content compared to only TPA treated group (p < 0.05). Furthermore, histological analysis clearly confirmed that Gin-Re inhibited the inflammatory responses of skin inflammation in animal model. Gin-Re was responded well in inhibiting paw thickness, MDA level and also NO level in carrageenan induced paw edema model compared to only carrageenan treated group. Treatment with Gin-Re inhibited secretion levels of inflammatory mediators such as tumor necrosis factor 伪 (TNF 伪), and interleukin-1尾 (IL-1尾) in LPS-stimulated murine macrophage Raw 264.7 cells. Despite the fact that Gin-Re has weaker anti-inflammatory potential than the positive controls, indomethacin and hydrocortisone, in the entire group tested, quite effective anti-inflammatory activity was shown by Gin-Re, which could be helpful to develop medicinal preparations for various inflammatory diseases.