Effect of gamma irradiation on the conversion of ginsenoside Rb1 to Rg3

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• 作者：Jae-Hun Kim^a ; ^{jaehun@kaeri.re.kr} ; Sun-Kyu Kwon^a ; Nak-Yun Sung^a ; Pil-Mun Jung^a ; Jong-il Choi^a ; Jae-Kyung Kim^a ; Arun K. Sharma^b ; Ju-Woon Lee^a
• 关键词：Gamma-irradiation ; Ginseng ; Ginsenoside Rb1 ; Ginsenoside Rb3 ; Cytotoxicity
• 刊名：Radiation Physics and Chemistry
• 出版年：2012
• 期刊代码：68_0969806x
• 类别：ph
• 出版时间：August, 2012
• 卷：81
• 期：8
• 页码：1128-1131
• 文件大小：333 K

摘要

Ginsenosides, the most important secondary metabolites in ginseng, have various biological activities. Many studies have focused on the conversion of one of the major ginsenosides, Rb1, to the more active minor ginsenoside, Rg3. This study was carried out to investigate the effect of gamma irradiation on the conversion of Rb1 to Rg3. Rb1 solutions were gamma-irradiated at doses of 10 and 30 kGy and analyzed by high performance liquid chromatography (HPLC). HPLC chromatograms showed a decreased content of Rb1 with increasing irradiation dose, but the content of Rg3 was increased. The highest content of Rg3 was present in the 30 kGy-irradiated Rb1 sample. The cytotoxic effects tested in cancer cell lines were increased in the gamma-irradiated group. Therefore, these results suggest that gamma irradiation can be an effective method for the conversion of the ginsenoside Rb1 to Rg3.