Hyperbaric oxygen therapy reduces the size of Leishmania amazonensis-induced soft tissue lesions in mice
- 作者：Wagner Welber Arrais-Silva ; Eduardo Fonseca Pinto ; Bartira Rossi-Bergmann and Selma Giorgio
- 关键词：Leishmaniasis ; Leishmania amazonensis ; Hyperbaric oxygen
- 刊名：Acta Tropica
- 出版年：2006
- 期刊代码：2_0001706x
- 类别：imm
- 出版时间：May 2006
- 卷：98
- 期：2
- 页码：130-136
- 文件大小：366 K
摘要
In this study we determined whether exposing mice to hyperbaric oxygen (HBO) would alter various disease parameters of a susceptible mouse strain infected with Leishmania amazonensis. BALB/c mice exposed to HBO (100%O2 at a pressure of 2.5 ATA, 1 h before parasite inoculation and subsequently for 20 days) showed significant delay in lesion development and reduction in lesion parasite burdens compared with HBO-unexposed mice. Circulating levels of interferon gamma (IFN-γ) and tumor necrosis factor (TNF-α) were significantly elevated in HBO-exposed as compared to HBO-unexposed mice. Concanavalin A-stimulated lymph nodes cultures from HBO-exposed mice released significantly more IFN-γ and less interleukin 10 (IL-10) than cultures from HBO-unexposed mice, consistent with a skewed Th1 response. These results demonstrate, for the first time, that HBO can play a pathogen control role during leishmaniasis. Further studies are needed to elucidate whether hyperoxia alone or increased atmospheric pressure alone can exert a similar effect.