Filling the gap: Chemistry of 3,5-bis(trifluoromethyl)-1H-pyrazoles

详细信息	查看全文 | 推荐本文 |

• 作者：Angelo Maspero^a ; ^{angelo.maspero@uninsubria.it} ; Giovanni B. Giovenzana^b ; Damiano Monticelli^a ; Silvia Tagliapietra^c ; Giovanni Palmisano^a ; Andrea Penoni^a
• 关键词：Pyrazoles ; Electrophilic aromatic substitution ; Heterocycles
• 刊名：Journal of Fluorine Chemistry
• 出版年：2012
• 期刊代码：52_00221139
• 类别：ch
• 出版时间：July, 2012
• 卷：139
• 期：Complete
• 页码：53-57
• 文件大小：261 K

摘要

Pyrazoles represent important building blocks for the preparation of bioactive compounds and a large variety of materials, due to their rich coordination chemistry. Unusual and interesting properties may be imparted to molecules embodying highly fluorinated pyrazoles, but to date only few examples of polyfluorinated pyrazoles have been described. In this work we report an improved preparation of 3,5-bis(trifluoromethyl)-1H-pyrazole, the subsequent transformation into hitherto unknown 4-functionalized (F, Cl, Br, I, NO₂, NH₂) derivatives and the evaluation of selected chemical and physical properties of these compounds.