HLA-Cw allele frequencies in northern and southern Italy
- 作者：Franca R Guerini ; Caterina Fusco ; Benedetta Mazzi ; Biagio Favoino ; Giustina Nocera ; Cristina Agliardi ; Daniela Ceresa ; Maria Valentino ; Donata Mininni ; Milena Zanzottera ; Pasquale Ferrante ; Maria L L
- 关键词：Allele frequencies ; HLA-Cw ; Italian population ; Molecular typing
- 刊名：Transplant Immunology
- 出版年：2008
- 期刊代码：251_09663274
- 类别：med
- 出版时间：January 2008
- 卷：18
- 期：3
- 页码：286-289
- 文件大小：141 K
摘要
The evidence for HLA-Cw antigens' involvement in the modulation of the immune response in bone marrow transplantation, NK alloreactivity and the susceptibility and follow-up for different diseases has been growing in the recent years, but very few data on HLA-Cw distribution in healthy Italian subjects are available to date. This report presents an updated description of HLA-Cw frequencies in Italy, comparing data from the northern (Lombardia) and southern (Campania and Puglia) parts of the country. A total of 1101 healthy subjects of Italian origin were genotyped, and the results showed that HLA-Cw
04, Cw07, Cw12, and, in particular, Cw0401, Cw0701, Cw1203, were the most frequent alleles found in all three regions analysed. Nevertheless, statistically significant differences were observed in Cw07 distribution, which was more frequent in the southern than in the northern part of Italy (28.8%vs 22.4%; p = 0.001; OR: 1.4; 95%CI: 1.14–1.73), and in Cw12 distribution, which was more frequent in the north than the south (17.0%vs 12.4%; p = 0.007, OR: 1.4; 95%CI: 1.10–1.91). These results, which give an improved pattern of distribution of HLA-Cw alleles in the Italian population, would be useful in bone marrow transplantation and anthropological studies. Moreover, due to the important role of HLA-Cw antigens in modulation of the immune response and NK alloreactivity, these data would be of interest in studies on susceptibility, follow-up and/or protection against different diseases.
04, Cw07, Cw12, and, in particular, Cw0401, Cw0701, Cw1203, were the most frequent alleles found in all three regions analysed. Nevertheless, statistically significant differences were observed in Cw07 distribution, which was more frequent in the southern than in the northern part of Italy (28.8%vs 22.4%; p = 0.001; OR: 1.4; 95%CI: 1.14–1.73), and in Cw12 distribution, which was more frequent in the north than the south (17.0%vs 12.4%; p = 0.007, OR: 1.4; 95%CI: 1.10–1.91). These results, which give an improved pattern of distribution of HLA-Cw alleles in the Italian population, would be useful in bone marrow transplantation and anthropological studies. Moreover, due to the important role of HLA-Cw antigens in modulation of the immune response and NK alloreactivity, these data would be of interest in studies on susceptibility, follow-up and/or protection against different diseases.