Sterically stabilized liposomes as a carrier for α-emitting radium and actinium radionuclides

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• 作者：Henriksen ; Gjermund ; Schoultz ; B.W. ; Michaelsen ; T.E. ; Bruland ; Ø ; .S. ; Larsen ; R.H.
• 关键词：Liposomes ; α ; -particle emitters ; ²²³Ra ; ²²⁴Ra ; ²²⁵Ac
• 刊名：Nuclear Medicine and Biology
• 出版年：2004
• 期刊代码：43_09698051
• 类别：ph
• 出版时间：May, 2004
• 卷：31
• 期：4
• 页码：441-449
• 文件大小：203 K

摘要

The α-particle emitting radionuclides ²²³Ra (t = 11.4 d), ²²⁴Ra (t = 3.6 d), and ²²⁵Ac(t = 10.0 d) may have a broad application in targeted radiotherapy provided that they could be linked to vehicles with tumor affinity. The potential usefulness of liposomes as carriers was studied in the present work. Radium and actinium radionuclides could be loaded in good yields into sterically stabilized lipsomes. Subsequent coating of the lipsomes with a folate-F(ab′)₂ construct yielded a product with affinity towards tumor cells expressing folate receptors. Radionuclide loaded liposomes showed excellent stability in serum in vitro.