Optimisation of cyclotron production parameters for the ²⁰⁹Bi(α, 2n) ²¹¹At reaction related to biomedical use of ²¹¹At

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• 作者：Henriksen ; Gjermund ; Messelt ; Svein ; Olsen ; Eivind ; Larsen ; Roy H.
• 关键词：²¹⁰At ; ²¹¹At ; ²¹⁰Po ; Alpha emitters ; Energy calibration ; Beam optimisation
• 刊名：Applied Radiation and Isotopes
• 出版年：2001
• 期刊代码：6_09698043
• 类别：ce
• 出版时间：May, 2001
• 卷：54
• 期：5
• 页码：839-844
• 文件大小：181 K

摘要

The cyclotron alpha beam production of ²¹¹At and of the contaminant ²¹⁰At related to beam energy were studied. Radiochemical purification of ²¹¹At from the other main contaminant, ²¹⁰Po, by an extraction procedure was also evaluated. To avoid impurities 28MeV has previously been considered as a maximum beam energy, but by using instead 29.1MeV as a limit a large increase in EOB yield and sufficient radiochemical purity of extracted ²¹¹At were obtained. More cyclotrons could thereby deliver quantities useful for clinical cancer trials.