Carbon nanotubes-ionic liquid nanocomposites sensing platform for NADH oxidation and oxygen, glucose detection in blood

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• 作者：Lu Bai^a ; Dan Wen^a ; Jianyuan Yin^b ; Liu Deng^a ; Chengzhou Zhu^a ; Shaojun Dong^a ; ^{dongsj@ciac.jl.cn}
• 关键词：Carbon nanotubes ; Ionic liquid ; Electrochemical sensing ; Blood samples
• 刊名：Talanta
• 出版年：2012
• 期刊代码：106_00399140
• 类别：ch
• 出版时间：15 March, 2012
• 卷：91
• 期：Complete
• 页码：110-115
• 文件大小：835 K

摘要

An excellent electrochemical sensing platform has been designed by combining the huge specific surface area of carbon nanotubes (CNTs) and the remarkable conductivity of ionic liquid (IL). IL can easily untangle CNTs bundles and disperse CNTs by itself under grinding condition due to the 蟺-蟺 interaction between CNTs and IL. The resulting nanocomposites showed an augmentation on the voltammetric and amperometric behaviors of electrocatalytic activity toward O₂ and NADH. Therefore, such an efficient platform was developed to fabricate mediator-free oxygen sensor and glucose biosensor based on glucose dehydrogenase (GDH). O₂ could be determined in the range of zero to one hundred percent of O₂ content with the detection limit of 126 渭g L^鈭? (S/N = 3). The glucose biosensor which was constructed by entrapping GDH into chitosan on the nanocomposites modified glassy carbon electrode surface, exhibited good electrocatalytic oxidation toward glucose with a detection limit of 9 渭M in the linear range of 0.02-1 mM. We also applied the as-prepared sensors to detect oxygen and glucose in real blood samples and acquired satisfied results.