Inhibitory effect of Andrographolide in 3T3-L1 adipocytes differentiation through the PPAR纬 pathway

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• 作者：Lina Jin^a ; ¹ ; Wenqiang Fang^c ; ¹ ; Bo Li^a ; ^b ; Guojun Shi^a ; Xiaoying Li^a ; ^b ; Ying Yang^a ; Jian Yang^a ; Zhiguo Zhang^a ; ^{zhiguo1978@yahoo.com.cn} ; Guang Ning^a ; ^b
• 关键词：C/EBP ; CCAAT/enhancer-binding proteins ; FABP4 ; Fatty acid binding protein 4 ; FAS ; Fatty acid synthase ; GAPDH ; Glyceraldehyde-3-phosphate dehydrogease ; LPL ; Lipoprotein lipase ; PGC-1 ; Peroxisome proliferator-activated receptor-gamma coactivator 1 ; PPAR纬
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2012
• 期刊代码：109_03037207
• 类别：bio
• 出版时间：6 July, 2012
• 卷：358
• 期：1
• 页码：81-87
• 文件大小：1314 K

摘要

Andrographolide (AG), an active compound found in Andrographis paniculate Nees, has been shown to exert anti-inflammatory, anticancer and anti-hyperglycemic effects. However, its biological activities against obesity have not been reported. The purpose of this study was to investigate the effect of AG on the differentiation of 3T3-L1 preadipocytes. We found AG significantly inhibited not only on adipocyte differentiation induced by standard adipogenic agents and MDI, but also on the adipogenesis-related transcription factor, peroxisome proliferator-activated receptor 纬 (PPAR纬), as well as the expressions of the PPAR纬 targeted genes, such as CD36, LPL, FAS and other adiocyte markers. Taken together, our data showed AG inhibited the early stage of adipogenic differentiation, in part via the inhibition of PPAR纬-dependent mechanisms.