• 作者：Javier del Pino-Montes^a ; Ma Jesú ; s Garcí ; a de Yé ; benes Prous^b ; ^{Mjesus.garciadeyebenes@ser.es} ; Antonio Torrijos Eslava^c ; Antonio Morales Piga^d ; Jordi Carbonell Abelló ; ^e ; Jordi Farrerons Minguela^f ; Jesú ; s Garrido Garcí ; a^b ; Milena Gobbo Montoya^b ; Manuel Rodrí ; guez Pé ; rez^g ; Jesú ; s Tornero Molina^h ; Nuria Guañ ; abens Gayⁱ ; Loreto Carmona^b ; Grupo de trabajo del Registro (listado en el apé ; ndice)
• 关键词：Enfermedad de Paget ; Registro nacional ; Caracterí ; sticas de los sujetos
• 刊名：Reumatolog铆a Cl铆nica
• 出版年：2009
• 期刊代码：pca303_1699258X
• 类别：med
• 出版时间：May-June 2009
• 卷：5
• 期：3
• 页码：109-114
• 文件大小：164 K

Objectives

To describe the clinical and epidemiological characteristics of patients included in the National Register of Paget's disease.

Methods

A Register of patients with Paget disease (PD), radiologically confirmed, and pertaining to 25 hospitals was analysed. Clinical and epidemiological data were collected, including age, sex, date and presentations at time of diagnosis, treatment, quality of life (QL) (EuroQol 5D) and perceived health, environmental factors (profession, history of measles, contact with animals, dairy consumption, housing conditions, place of birth and address) and family history (PD history, origin of the ancestors, number of children). We conducted a statistical description of the data.

Results

The register included 602 patients with an average age of 62卤11 years and a predominance of male (55%). Of the patients included, 79%showed symptoms at the time of diagnosis, mainly pain (83%); 82%had received treatment, mainly bisphosphonates (47%more than one drug). Despite treatment, a significant proportion had limitations in their QL, especially related to pain (64%), mobility (47%) and anxiety/depression (33%). Most of the patients had been exposed to situations which were considered as risk factors. Of the patients included, 14%had family history of PD and 1.5%had children with PD. The ancestors of the familial cases came more frequently from Avila, Salamanca, La Coru帽a and Malaga.

Conclusions

The pain and the limitation of mobility decrease the QL of patients with PD despite treatment. Frequently, patients have a history of exposure to risk factors.