Hormone replacement therapy use is associated with a lower occurrence of carotid atherosclerotic plaques but not with intima-media thickness progression among postmenopausal women. The vascular aging

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• 作者：Le Gal ; Gré ; goire ; Gourlet ; Vé ; ronique ; Hogrel ; Patricia ; Plu-Bureau ; Geneviè ; ve ; et. al.
• 关键词：Hormone replacement therapy ; Arteriosclerosis ; Intima-media thickness ; Atherosclerotic plaques ; Carotid artery disease ; Longitudinal study
• 刊名：Atherosclerosis
• 出版年：2003
• 期刊代码：28_00219150
• 类别：med
• 出版时间：January, 2003
• 卷：166
• 期：1
• 页码：163-170
• 文件大小：125 K

摘要

Background: Information on the impact of hormone replacement therapy (HRT) on carotid atherosclerosis is limited. Moreover, transdermal estrogens have not been investigated. Methods: We examined association of HRT use with ultrasonographically assessed carotid atherosclerotic plaque occurrence and mean common carotid artery intima-media thickness (CCA–IMT) progression. Within the Vascular Aging (EVA) Study, a community-based cohort, 815 postmenopausal women aged 59–71 have been followed during 4 years. Among these women, 166 had already used HRT. Results: Women who had ever used HRT experienced a lower occurrence of plaques (8.6 versus 19.1%, P