Quantitative trait loci modulate vertebral morphology and mechanical properties in a population of 18-month-old genetically heterogeneous mice

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• 作者：Grant M. Reeves ; Barbara R. McCreadie ; Shu Chen ; Andrzej T. Galecki ; David T. Burke ; Richard A. Miller ; Steven A. Goldstein
• 关键词：Quantitative trait loci ; Genetic ; Mice ; Mechanical property ; Geometry
• 刊名：Bone
• 出版年：2007
• 期刊代码：39_87563282
• 类别：med
• 出版时间：February 2007
• 卷：40
• 期：2
• 页码：433-443
• 文件大小：1181 K

摘要

The aim of this study was to examine effects of polymorphic genes on vertebral bone morphology and mechanical properties. Genotypes from 525 18-month-old female mice were compared to geometric traits obtained from micro-computed tomography and mechanical properties from compression testing. Genetic markers were associated with traits on at least 13 different chromosomes, demonstrating the complexity of genetic control over vertebral form, function and aging.