Detection of KPC-2 and qnrS1 in clinical isolates of Morganella morganii from China
- 作者：Jia Chang Cai ; Wei Yang ; Yan Yan Hu ; Rong Zhang ; Hong Wei Zhou ; Gong-Xiang Chen ; chengong218@163.com
- 关键词：Antimicrobial resistance ; Carbapenems ; Enterobacteriaceae
- 刊名：Diagnostic Microbiology and Infectious Disease
- 出版年：2012
- 期刊代码：79_07328893
- 类别：med
- 出版时间：June, 2012
- 卷：73
- 期：2
- 页码：207-209
- 文件大小：138 K
摘要
Seven carbapenem-nonsusceptible Morganella morganii isolates, which have similar antibiotic susceptibility profiles, were isolated over a 5-month period. MICs of imipenem, meropenem, and ertapenem were 8, 1, and 0.25 to 0.5 渭g/mL, respectively. Pulsed-field gel electrophoresis indicated that 6 isolates were indistinguishable or closely related. Carbapenem resistance can be transferred from M. morganii to Escherichia coli by conjugation. All M. morganii isolates and E. coli transconjugants produced KPC-2 and carried the qnrS1 gene. Production of KPC-2 mainly contributed to the carbapenem resistance in M. morganii. KPC-2-producing M. morganii clonally spread in a hospital in China.