Chimioth脙脙脙脙rapie adjuvante pour le cancer du colon de stades Dukes B2 et C comportant du 5-fluorouracile et de l'acide folinique, avec ou sans carboplatine. Faisabilit脙脙脙脙 et comparaison d'un

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• 作者：Focan ; C. ; Bury ; J. ; Matus ; G. ; Graas ; M.P. ; Kreutz ; F. ; Longree ; L. ; Moeneclaey ; N. ; David ; A. ; et. al.
• 关键词：Colon cancer ; Adjuvant therapy ; Chronotherapy ; Ambulatory medicine
• 刊名：Pathologie Biologie
• 出版年：2005
• 期刊代码：216_03698114
• 类别：med
• 出版时间：June, 2005
• 卷：53
• 期：5
• 页码：281-284
• 文件大小：160 K

摘要

Thirty-seven patients operated from a Dukes B2-C colon cancer were randomised to receive as adjuvant infusional chemotherapy, nine 5 FU and folinic acid courses with or without carboplatin, as standard (de Gramont ; 2 days every 2 weeks) or chronomodulated administration (4 days every 2 weeks). The overall tolerance was judged excellent with less than 7%courses with dose-adaptations. The two carboplatin arms presented an enhanced haematological toxicity, while some more cutaneous toxicity was observed in the chronomodulated arm with the three drugs.