Genetic variability of Echinococcus granulosus sensu stricto in Europe inferred by mitochondrial DNA sequences

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• 作者：Adriano Casulli^a ; ^{adriano.casulli@iss.it} ; Maria Interisano^a ; Tamas Sreter^b ; Lidia Chitimia^c ; Zvezdelina Kirkova^d ; Giuseppe La Rosa^a ; Edoardo Pozio^a
• 关键词：Echinococcus granulosus ; Molecular epidemiology ; Population genetic structure ; Europe
• 刊名：Infection ; Genetics and Evolution
• 出版年：2012
• 期刊代码：119_15671348
• 类别：med
• 出版时间：March, 2012
• 卷：12
• 期：2
• 页码：377-383
• 文件大小：261 K

摘要

The genetic diversity of <em>Echinococcus granulosusem> sensu stricto (s.s.) metacestodes from four European countries was evaluated by the DNA sequence analysis of the cytochrome c oxidase subunit 1 (<em>cox1em>) mitochondrial gene. Of the 312 organisms investigated, 132 were from Bulgaria, 35 from Hungary, 89 from Italy and 56 from Romania. Considerable intraspecific variation was observed in the mitochondrial <em>cox1em> sequences: 24 haplotypes were detected in the Eastern European population and seven in the Italian population. The Eastern European population parsimony network displayed a star-like features consisting of the most common haplotype EG1 (G1 genotype) and the three major haplotypes: EG2, EG3 and EG4. The EG1 was also the major haplotype in the Italian population network, though with a higher prevalence (73%) compared to the Eastern European network. The percentage of the population constituted by the G1 genotype was used as an indirect index to evaluate the genetic diversity within <em>E. granulosusem> s.s. populations of Eurasia. A clinal correlation between the percentage of the G1 genotype and the geographical regions of Eurasia was observed: the G1 genotype is highly represented in the Mediterranean Basin; it decreases in Eastern Europe and South-West Asia and increases in China. This clinal correlation could reflect the spreading of livestock domestication from Southern-Western Asia during the Neolithic period, beginning around 12,000 BC.