NF-κB precursor, p105, and NF-κB inhibitor, IκBγ, are both elevated in Alzheimer disease brain

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• 作者：Huang ; Yu ; Liu ; Fei ; Grundke-Iqbal ; Inge ; Iqbal ; Khalid ; Gong ; Cheng-Xin
• 关键词：NF-κ ; B precursor ; Iκ ; Bγ ; Alzheimer disease ; Human brain
• 刊名：Neuroscience Letters
• 出版年：2005
• 期刊代码：52_03043940
• 类别：neu
• 出版时间：January 10, 2005
• 卷：373
• 期：2
• 页码：115-118
• 文件大小：162 K

摘要

The nuclear factor-κB (NF-κB) signal transduction pathway regulates several vital cellular processes. During our studies of the glycoproteins involved in Alzheimer disease (AD), we found a significant increase of a 45-kDa protein band that was stained by lectin Maackia amurensis agglutinin (MAA). Mass spectrometry and Western blot analyses indicated that this 45-kDa MMA-positive protein was an inhibitor of NF-κB, IκBγ. By Western blot analysis, the levels of both IκBγ and NF-κB precursor, p105, were found to be elevated in AD brain as compared to age-matched controls. Our findings suggest that the NF-κB pathway might be involved in the molecular mechanism of AD.